Basic differences between macroemulsion and microemulsion 1214 sl. Identification of winsor type iii microemulsion for chemical eor of heavy oil authors steve sookhoon sim. Identification of winsor type iii microemulsion for. I have examined the final electronic copy of this dissertation for form and content and recommend that it be accepted in partial fulfillment of the requirements for the degree of doctor of philosophy, with a major in chemical engineering. In chapter 1 a short introduction about the background, various aspects and applications. Paper open access extraction and characterization of crude. Windsor manuals, marketing literature, and more we want you to be successful at what you do. Winsor phase behavior schlumberger oilfield glossary. A distinction among three phase behaviors of oil, water and surfactant systems when they form a microemulsion.
Microemulsions an introduction to properties and applications. Effect of cosurfactant on the supramolecular structure and. Formulation and characterization of microemulsion system. Microemulsion modelling is a computational tool developed to predict the optimal salinity of a crudesurfactantbrine ternary phase system. The free energy of microemulsion formation can be considered to depend on the extent to which surfactant lowers the surface tension of the oil water interface and change in entropy of the system such that, gf. For other materials, the microemulsion contains all above plus one. Microemulsion systems containing bioactive natural oils. List of surfactants commonly used in protein and peptide based microemulsion. A potential novel drug delivery system jaspreet kaur saini 1, ujjwal nautiyal 1, senthil kumar m 1, devendra singh 2, firoz anwar 3 1department of pharmaceutics, himachal institute of pharmacy, paonta sahib, himachal pradesh, india.
Historical background definition composition of microemulsion major goals advantages disadvantages macroemulsion vs microemulsion types of microemulsions preparation methods of microemulsions equipments used for the preparation of microemulsions formation of microemulsion factors affecting. Although for many applications single phase miroemulsions are of interest, it has been the intensive research on the conditions required to produce three phase equilibrium in a variety of systems that has lead. Oilinwater mes were formulated using surfactant s peg8 capryliccapric glycerides and cosurfactant cos polyglyceryl6isostearate. Aceclofenac, topical microemulsion, skin permeation, phase diagram. When oil is added, the cosurfactant activity in the continuous medium decreases and a. A platform for improving dissolution rate of poorly water soluble drug surjyanarayan mandal and snigdha. Several laboratory experiments were conducted to determine the rheological behavior of surfactant solutions.
The objective of this study was to formulate optimal formulations of microemulsions mes and evaluate their feasibility for delivery of resveratrol into human skin ex vivo. Simultaneous presenceof two microemulsion phases, one in contact with water and the other in contact with oil is also possible. Microemulsions are clear, thermodynamically stable, isotropic liquid mixtures of oil, water and. Although the terms colloid and emulsion are sometimes used interchangeably, emulsion should. Glimepiride loaded microemulsion using labrafil m 1944 cs, cremophor rh 40, transcutol p as oil, surfactant and cosurfactant respectively, was prepared and characterized. Armenta, in comprehensive analytical chemistry, 2011. Winsors classification is used to study the phase diagram dantas et al. Cationic microemulsion polymerization of alkyl acrylates. Moldings classic american molding collection windsorone. Pg as surfactantcosurfactant mixture scos in ratio of 15.
Surfactants for microemulsions conxita solans and maria jose garciacelmat research effort in past years has focused on the evelopment of microemulsions with specific properties, namely, high solubilizing power and temperature insensitivity. In this paper, we are going to discuss two main topics. Microemulsion phase behavior the main features of microemulsion phase behavior have already been described by winsor in the 1950s 5. An me gel base composed of 35% ipm, 20% water, and 45% tween 80. Effect of branched alcohols on phase behavior and physicochemical properties of winsor iv microemulsions article pdf available in journal of surfactants and detergents 172 march 2014 with. The first three component microemulsion polymerization water, surfactant and monomer was reported by perezluna et al. Windsor i a two phase system with an ow micellar dispersion and an excess oil phase windsor ii a two phase system with a wo micellar dispersion and an excess water phase windsor iii ow a three phase system with a. Hydergine gift samples from ivax pharmaceuticals s. Experimental design 3 2 was applied in the formulation of microemulsion by varying concentrations levels of oil and s mix and measuring globule size gs and drug. Insulin microemulsion wo following nasal administration showed a 3040% drop in blood glucose level at a dose of 1 iukg 177. Characterization of microemulsions prepared using isopropyl. Pdf on aug 1, 2017, mohsen tagavifar and others published measurement of microemulsion viscosity and its implications for chemical enhanced oil. In figure 1, system a, the st microstructure represents a region of transition between microstructure of liquid microemulsions. Pdf effect of branched alcohols on phase behavior and.
Sep 09, 2009 preparation of the microemulsion base and microemulsion systems containing different concentrations of salicylic acid. Microemulsion is a nanoparticle synthesis technique in which two immiscible fluids such as water in oil wo, oil in water ow or water in supercritical carbon dioxide wsc co2 are thermodynamically stabilized with the aid of a surfactant. Preparation of the microemulsion base and microemulsion systems containing different concentrations of salicylic acid. Protein extraction by winsoriii microemulsion systems. These therapeutic macromolecules in microemulsion drug delivery form is not. Microemulsions are thermodynamically stable mixtures of oil and water. Naproxen is poorly water solubility and it is possible to increase its solubility by utilizing microemulsion systems. They are the border between lyophilic and lyophobic. Oil and water are immiscible and they separate into two phases when mixed, each saturated with traces of the other component capek, 1999. Microemulsions are mixtures of oil, surfactant, and water that form spontaneously on bringing the three components together 69. Identification of winsor type iii microemulsion for chemical eor of heavy oil. Lindman 1 a microemulsion is a system of water, oil and an amphiphile which is a single optically isotropic and thermodynamically stable liquid solution. Phase diagram can be constructed by water titration method rohit ramesh shah et.
Historical background definition composition of microemulsion major goals advantages disadvantages macroemulsion vs microemulsion types of microemulsions preparation methods of microemulsions equipments used for the preparation of microemulsions formation of microemulsion. They also look stunning when used in conjunction with the four windsorone molding styles. Basic aspects of microemulsion microemulsion are fluid, transparent, thermodynamically stable oil and water system and stabilized by a surfactant usually in conjunction with cosurfactant. Identification of winsor type iii microemulsion for chemical. Microemulsions are thermodynamically stable, and their formation is facilitated by the ultralow interfacial tension of these systems, which leads to. Feb 07, 20 naproxen is poorly water solubility and it is possible to increase its solubility by utilizing microemulsion systems. Both ow and wo microemulsion can be used for parenteral delivery. Enhanced oil recovery a distinction among three phase behaviors of oil, water and surfactant systems when they form a microemulsion. Emulsions part 3 microemulsions miniemulsions remarks to.
Pharm quality assurance department of pharmaceutics faculty of pharmacy jamia hamdard new delhi 110062 supervisor dr. In some respects, microemulsions can be considered as smallscale. Sep 24, 2014 the trend of growing interest in alternative source of energy focuses on renewable products worldwide. This situation is ideal to achieve ultralow interfacial tension values and is favorable for eor. Extraction of proteins by winsor iii microemulsion systems.
Effect of surfactant type on formation of microemulsions. Design and characterization of microemulsion systems for naproxen. Three components are the basic requirement to form a microemulsion. Rio entitled extraction of proteins by winsor iii microemulsion systems. Based on the ellipse rather than the circle, the greek revival style was founded on the principles of classic greek architecture. Design and formulation of optimized microemulsions for dermal. Pdf measurement of microemulsion viscosity and its implications. Application of phase behavior studies to optimize chemical formulation for heavy oil eor is not very common due to difficulties in identifying microemulsion in the presence of highly viscous and opaque crude oil.
Microemulsion phase sequence as a function of temperature and salinity for nonionic and ionic surfactants, respectively. Isbn 9789535102472, pdf isbn 9789535149712, published 20120316. Polyisobutyl cyanoacrylate pbca nanocapsules dispersed in a biocompatible microemulsion resulted in a significant reduction in blood glucose levels in diabetic rats compared to an aqueous insulin solution 178. Interfacial tension, measurement, effect of surfactant on oil. A novel dualionic liquid il microemulsion system is developed with il 1 decyl3methylimidazolium bromide dmimbr as the surfactant and il 1 butyl3methylimidazolium hexaflourophosphate. An emulsion is a mixture of two or more liquids that are normally immiscible unmixable or unblendable.
For modified lecithin, the microemulsion contains at least one metal chelate complex, at least one surfactant such as an anionic surfactant, modified lecithin, water, and optionally at least one alcohol. This book provides an assessment of some issues influencing the characteristics and performance of the microemulsions, as well as their main types of applications. Gel microemulsion region occurs within the aqueous phase limits of 35 and 50% and it is followed by a semitransparent phase st up to 60% of aqueous phase. Microemulsion domains are usually characterized by constructing ternaryphase diagrams. Enter the type of service you are looking for or the agencyprogram name into the box at the top of the search tool below. This phase is a continuous layer containing surfactant, water and dissolved hydrocarbons. Stoffer and bone 3,4 first reported microemulsion polymerization in 1980. Where the concentration of surfactant is not restricted to a 1. The aim of the present study was to design novel ow microemulsion of glimepiride and to study its. Figure 5 shows the pseudoternary phase diagram with the area inside the frame assigned on the phase diagram showing the microemulsion region.
In a microemulsion the domains of the dispersed phase are either. Nov 21, 2014 the microemulsion definition provided by danielson and lindman in 1981 will be used as the point of reference. A study of microemulsion viscosity with consideration of. To see results for a specific county, city, andor zip code, enter the information into one or more of the boxes below look for resources in or near a location before you hit the search for resources button. Journal of pharmaceutical, chemical and biological sciences, february 2014. The ratios of surfactant to cosurfactants were chosen to be 1. I have examined the final electronic copy of this dissertation for form and content and recommend that it be accepted in partial fulfillment of the requirements for the degree of doctor of philosophy, with a. Microemulsion formulations have distinct advantages over macroemulsion systems when delivered parenterally because of the fine particle microemulsion is cleared more slowly than the coarse particle emulsion and, therefore, have a longer residence time in the body. Low investment cost, high production rate, and simplicity of maintenance. Whilst optimal salinity is associated with the desirable windsor typeiii microemulsion, other types of microemulsion can be determined from.
A microemulsion forming systems is shown in figure 1. Aerosol ot, mediumchain triglycerides with oleic acid oil phases 1. The average drug transport rate of optimized hydrogel thickened microemulsion containing 1 % ww lornoxicam, 10 % ww oily phase of camphor. Polyoxyethylene within the water droplets of a wo microemulsion. The structure of liquid surfactantwateroil mixtures, so called microemulsions, is discussed.
This may be considered as an extension of w insors classification form ing the fifth category. A microemulsion is an emulsion which forms spontaneously, without mechanical action, from a mixture of two liquid phases under certain conditions. Formulation of a new oilinwater ow microemulsion composed of castor oiltween 80ethanolphosphate buffer for enhancing the loading capacity of an antiinflammatory drug piroxicam has been accomplished. Most microemulsion polymerization reported in the 80s, were carried out in four and five component systems 2. Stock moulding profiles hatfield, ma portland, me wilmington, ma 0315 clear pine fjp 8276 fence cap 118 x 4 fence cap 34 dado parting bead 1 2. A new empirical model for the viscosity of microemulsion phase as a function of salinity is introduced. Microemulsion as drug delivery system for peptides and proteins.
Topical antiacne microemulsion formulation of essential. Preparation and evaluation of aceclofenac topical microemulsion. Eine mikroemulsion ist eine emulsion, deren disperse phase z. Phase behavior studies have provided the foundations for this development. The present invention provides a storage stable microemulsion formulation for modified lecithin as well as other materials. The pseudoternary phase diagram has been delineated at constant surfactantcosurfactant ratio 1. Mandal baroda college of pharmacy, vadodara, india.
Definition and history one of the best definitions of microemulsions is from danielsson and lindman 1 a microemulsion is a system of water, oil and an amphiphile which is a single optically isotropic and thermodynamically stable liquid solution. Emulsions are part of a more general class of twophase systems of matter called colloids. The majority of microemulsions use oil and water as immiscible liquid pairs. Design and characterization of microemulsion systems for. Polyoxyethylene adsorption in wateroil microemulsions. Here you can download advertisements, discontinued product information, brochures, enduser guides, material safety data sheets, parts lists, sell sheets, service manuals, warranty. Preparation, optimization and characterization of microemulsions 168 table 5. Accelerated stability study of the developed microemulsion was carried out for 6 months. The effect of surfactant type on microemulsion area is shown in figure 1 and indicates that the best surfactant to produce microemulsion is in the following rank order. In a winsor type iii system, the surfactant forms a microemulsion in a separate phase between the oil and aqueous phases. Pdf microemulsion systems containing bioactive natural oils. However, the situation of petroleum industries in many countries needs much concern in improving the oil recovery technique. They are generally described as windsor type i, ii, iii or iv emulsions fig. The chariot 2 iscrub 20 deluxe is sure to exceed your.
These include micelles, colloids, gels, networks, etc, and could be referred to as micellar systems. Preparation and evaluation of microemulsion systems. Brent hull, a graduate of the prestigious north bennett street school and historic millwork expert, designed the historically accurate windsorone molding collection. Drug solubilization capacity of the microemulsion system was determined. Microemulsions containing 1% ww aceclofenac were formulated and. Formulation and evaluation of microemulsion based topical. The microemulsion was nonirritant, ensured adequate protection from drug degradation, provided prolonged release, and was found to be suitable for longterm. The model consists of three different correlations one for each phase type of windsor. Design and formulation of optimized microemulsions for. The rapidly increasing number of applications for microemulsions has kept this relatively old topic still at the top point of research themes. A microemulsion comprised of oleic acid 6%, tween 80 20%, propylene glycol 10%, and menthol 1 % in water 62. Chemical method, especially microemulsion flooding, plays an important role in enhanced oil recovery technique due to its ability to reduce interfacial tension between. Thanks for helping us catch any problems with articles on deepdyve.
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